Collaboration

Interested in a collaboration?

We have a strong a record in academic and industrial collaborations and have published structures together with Alexion Pharmaceuticals, Inc and NOXXON Pharma, revealing how the monoclonal antibody eculizumab and the SpiegelmerĀ® NOX-D20 interacts with native C5 and C5a, respectively (see below).

Such collaborations are of great importance to the biomedical society and we are always in search for new ones. Therefore, do not hesitate to contact us if you are interested in any of the following collaborations:

Proprietary research agreement (industry)

Sponsored research agreement (industry)

Academic research collaborations

For the industry collaborations, the overhead of proprietary research agreements are higher than for sponsored research agreements. Regarding academic research, we are interested in collaborations which include us being part of grant applications or in the case we perform preliminary work for your project that will lead to us being part of grant applications.

 

The structure of C5 bound to eculizumab

In collaboration with Alexion Pharmaceuticals we determined the structure of native C5 bound to a Fab-fragment with the same sequence as eculizumab, revealing how the cleavage of C5 is hindered in the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) (Schatz-Jakobsen et al. 2016, Journal of Immunology).

Click here to read the article.

The figure illustrates how eculizumab (green) binds C5 (sand), in this way inhibiting the cleavage of C5 by the native convertases

 

C5a inhibition by NOX-D20

In collaboration with NOXXON Pharma we determined the structure of C5a bound to the SpeigelmerĀ® NOX-D20, revealing how the aptamer shields important residues of C5a that is crucial for the binding and signaling through C5aR1 (Yatime et al. 2015, Nature Communications).

Click here to read the article.

The figure reveals how NOX-D20 (orange and blue) interacts with and shields important C5aR1 interacting residues (pink balls) of C5a (yellow)