Yeast Sub2p has a conserved N-terminal domain

Sub2p NTM motifToday, we published a paper in RNA together with the Torben Heick Jensen and Eckhard Jankowsky labs that shows, both experimentally and by using bioinformatics, that the S. cerevisiae helices Sub2p contains a hitherto uncharacterised N-terminal domain with a sequence signature reminiscent of the ubiquitin… We also show, using biochemical assays, that the N-terminal domain does not affect the main helices functions, ATPase activity, RNA binding, and RNA unwinding.

For more information, have a look at the paper in RNA.

Saguez, C., Gonzales, F. A., Schmid, M., Bøggild, A., Latrick, C. M., Malagon, F., Putnam, A., Sanderson, L., Jankowsky, E., Brodersen, D. E., Jensen, T. J. (2013) “Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export and genomic stability”, RNA, 19(10):1363-71.