VapC20 of M. tuberculosis cleaves the SRL of 23S rRNA

tRNA(fMet) and the SRL of 23S rRNAToday, a joint publication with the Gerdes group appeared online in Nature Communications. In this paper, we describe how the VapC20 toxin (VapBC-type) of Mycobacterium tuberculosis specifically cleaves the sarcin-ricin loop (SRL) of 23S ribosomal RNA when activated. We further show that the structure of the SRL is surprisingly similar to that of a tRNA anticodon stem loop (ASL) suggesting that VapC-type toxins bind and cleave RNA targets with similar structure.

For more information, have a look at the paper in Nature Communications.

Winther, K. S., Brodersen, D. E., Brown, A. K., Gerdes, K. (2013), “VapC of Mycobacterium tuberculosis Inhibits Translation by Endonucleolytic Cleavage of the Sarcin-Ricin Loop of 23S rRNA”, Nature Commun, 4:2796.