Proposed non-ribosomal peptide synthesis pathway required for formation of the bioactive compound, sansalvamide

Today, our lab published a joint paper with the fungal genetics group at Aalborg University headed by Prof. Henriette Giese. In the paper, we demonstrate using genetic knock-out strains, which non-ribosomal peptide synthetase is responsible for production of the potential anti-cancer drug, sansalvamide.

For more information, have a look at the paper in Current Genetics.

Romans-Fuertes, P., Søndergaard, T. E., Sandmann, M. I., Wollenberg, R. D., Nielsen, K. F., Hansen, F. T., Giese, H., Brodersen, D. E., and Sørensen, J. L. (2016) “Identification of the non-ribosomal peptide synthetase responsible for biosynthesis of the potential anti-cancer drug sansalvamide in Fusarium solani”, Curr Genet, 62(4):799-807.