Microbial Defence Mechanisms

Welcome to the home page of the Ditlev Brodersen Lab at the Department of Molecular Biology and Genetics at Aarhus University, Denmark.

Review on PIN domains in Protein Science (Senissar et al., 2017)

We are interested in the molecular and structural basis for microbial defence mechanisms, in particular bacterial stress response and persistence phenomena.

To study the function and molecular structure of enzymes, we employ biochemistry, x-ray crystallography, single-particle electron microscopy, and small-angle x-ray scattering.

Our research is focused on bacterial stress response mechanisms, including toxin-antitoxin systems and the structural basis for persistence. But we also work on large enzyme complexes such as the 240 kDa E. coli carbon-phosphorus lyase complex, responsible for utilisation of phosphonate compounds in gram-negative bacteria.

Crystal structure of the Caulobacter crescentus VapBC:DNA complex (Bendtsen et al., NAR, 2017).

Go to the Research section to learn more about our research projects, or take some time to browse our Publications.  For a presentation of our work in layman’s terms, see the Press section. Our lab is also involved in Methods development in protein x-ray crystallography.

We are also actively engaged in developing teaching methods at the university level. Go to the Teaching section to learn more about this. To learn more about who we are and what we do outside work hours, be sure to check out the list of Lab Members and our Gallery.